Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma.
نویسندگان
چکیده
Activation of the enzyme PLC (phospholipase C) leads to the formation of second messengers Ins(1,4,5)P(3) and diacylglycerol. RTKs (receptor tyrosine kinases) activate this reaction through PLCgamma isoenzymes. It has been shown that PI3K (phosphoinositide 3-kinase) may regulate PLCgamma activity through the interaction of PI3K product PtdIns(3,4,5)P(3) and the PLCgamma PH domain (pleckstrin homology domain). Here, we analyse the potential functional roles of the PI3K/PLC pathway.
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عنوان ژورنال:
- Biochemical Society transactions
دوره 35 Pt 2 شماره
صفحات -
تاریخ انتشار 2007